Fig. 1

Regions depicted by significance and effect size according to test cases reported in Table 1. a–c Framed with ‘Const 5 min’ scheme d–f framed with ‘Const Trues’ scheme. a and d Cases A-1 and B-1 balanced samples by the number of S and nS, b and e Cases A-2 and B-2 unbalanced samples by the number of S and nS, c and f Cases A-3 and B-3 additional case of unbalanced samples by the number of S and nS. Here, 2 nS were randomly removed, and one additional S per group was added to simulate changes in the groups differing to cases A-2 and B-2 obtained with the same random method but differing in the nS removed from each group