Optimization of the radiation dosimetry protocol in Lutetium-177-PSMA therapy: toward clinical implementation

EJNMMI Research

Table 4 The uncertainty u(D), Lin’s concordance correlation coefficient ρ_C and the normalized error E_N for the simplified dosimetry protocols for the salivary glands

Method	u(D) (%)	ρ_C	E_N
*1 h*	*17.1* ± *0.2*	*0.95*	*0.87* ± *0.54*
24 h	13.8 ± 0.3	0.91	1.50 ± 0.96
*48 h*	*12.2* ± *0.0*	*0.99*	*0.56* ± *0.32*
*72 h*	*13.8* ± *0.3*	*0.95*	*0.95* ± *0.52*
168 h	33.4 ± 5.3	0.86	1.55 ± 1.09
*1 h* + *168 h*	*11.6* ± *0.1*	*0.98*	*0.66* ± *0.34*
*24 h* + *168 h*	*11.4* ± *0.1*	*0.98*	*0.70* ± *0.59*
48 h + 168 h	11.2 ± 0.0	0.82	1.95 ± 0.32
72 h + 168 h	11.2 ± 0.0	0.45	3.67 ± 0.40

Mean ± SD values are given. Parameters that meet requirements are marked in bold. Protocols where all parameters meet requirements are marked in bolditalics