Optimization of the radiation dosimetry protocol in Lutetium-177-PSMA therapy: toward clinical implementation

EJNMMI Research

Table 2 The uncertainty u(D), Lin’s concordance correlation coefficient ρ_C and the normalized error E_N for the simplified dosimetry protocols for the lesions

Method	u(D) (%)	ρ_C	E_N
1 h	24.3 ± 1.1	0.79	3.65 ± 1.86
24 h	21.2 ± 1.2	0.96	1.82 ± 1.32
48 h	17.5 ± 2.3	0.94	2.30 ± 1.96
72 h	15.8 ± 1.6	0.94	1.60 ± 1.79
168 h	20.1 ± 1.3	0.98	1.21 ± 0.94
1 h + 24 h	20.3 ± 16.1	0.66	7.24 ± 4.75
1 h + 48 h	18.8 ± 11.6	0.77	5.01 ± 3.69
1 h + 72 h	16.2 ± 6.2	0.84	3.60 ± 2.02
*1 h* + *168 h*	*13.8* ± *2.0*	*0.99*	*0.68* ± *0.61*
24 h + 48 h	31.2 ± 24.9	0.77	3.69 ± 3.12
24 h + 72 h	18.7 ± 7.7	0.91	2.27 ± 1.97
*24 h* + *168 h*	*12.9* ± *2.3*	*0.99*	*0.65* ± *0.50*
48 h + 72 h	24.7 ± 18.1	0.92	2.79 ± 1.89
*48 h* + *168 h*	*13.1* ± *3.0*	*0.99*	*0.65* ± *0.64*
*72 h* + *168 h*	*13.4* ± *2.4*	*0.99*	*0.86* ± *0.48*

Mean ± SD values are given. Parameters that meet requirements are marked in bold. Protocols where all parameters meet requirements are marked in bolditalics