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Table 2 Results of the voxel-based group comparison (SPM12) showing the significant glucose metabolism differences in visual snow syndrome (VSS) patients compared to healthy controls (CON)

From: Simultaneous 18F-FDG PET/MR metabolic and structural changes in visual snow syndrome and diagnostic use

Cluster level

Voxel level

Peak voxel Talairach coordinate

Cluster peak intensity

Cluster location

PFWE-corr

Kext

Pheight (FWE)

T score

X

Y

Z

Δ% (%)

Anatomical region

(A.1) VSS > CON (pheight-FWE < 0.05 at voxel-level)

        

< 0.0001

656

< 0.0001

11.7

− 15

− 75

17

+ 24

L calcarine (BA18)

  

0.001

8.7

− 12

− 68

8

 

L lingual gyr (BA17)

< 0.0001

970

0.001

8.6

9

− 69

12

+ 24

R calcarine (BA17)

  

0.002

8.4

8

− 83

3

 

R calcarine (BA17)

(A.2) VSS > CON (pheight-uncorr < 0.001 at voxel-level)

        

< 0.0001

11,494

< 0.0001

11.7

− 15

− 75

17

+ 24

L Cuneus (BA18)

  

< 0.0001

8.7

− 12

− 68

8

 

L calcarine (BA17)

  

< 0.0001

8.6

9

− 69

12

 

R calcarine (BA17)

  

< 0.0001

8.0

− 12

− 101

− 3

 

L occip pole (BA17)

  

< 0.0001

7.0

− 2

− 87

0

 

L lingual gyr (BA17)

  

< 0.0001

6.8

50

− 75

− 6

 

R inf occip gyr (BA19)

0.004

1277

< 0.0001

6.6

45

− 63

− 53

+ 37

R CBL_VIIb

  

< 0.0001

6.4

38

− 60

− 60

 

R CBL_VIII

(B) VSS < CON (pheight-uncorr < 0.001 at voxel-level)

        

< 0.0001

12,006

< 0.0001

6.3

− 12

− 38

− 5

− 14

L parahpc gyr

  

< 0.0001

6.2

20

− 18

− 23

 

R parahpc gyr

  

< 0.0001

6.0

− 15

− 11

− 17

 

L HpC

  

< 0.0001

5.9

33

− 38

2

 

R HpC

  1. At voxel level pheight-cluster FWE-corr < 0.05 (A.1) and pheight-cluster uncorr < 0.001 (A.2 and B) with cluster extent 200 voxels
  2. BA Brodmann area, CBL cerebellum, HpC hippocampus, parahpc parahippocampus, L left, R right