Table 2 Kinetic parameters estimated using the 7-parameter and 5-parameter models (LEV: n = 4, BRV: n = 5)
Model | Region | AED | 11C-UCB-J | ||||||
|---|---|---|---|---|---|---|---|---|---|
AED | K1D(µL/cm3/min) | koffD(1/min) | VT (mL/cm3) | fND | K1 (mL/cm3/min) | koff(1/min) | |||
Displacement | Post-dose | ||||||||
7-parameter | Putamen | LEV | 6.2 (45%) | 4.2 (47%) | 22.2 (5%) | 0.075 (13%) | 0.46 (5%) | 0.49 (8%) | 5.5 (31%) |
Frontal cortex | LEV | 5.3 (42%) | 4.9 (71%) | 18.9 (5%) | 0.087 (13%) | 0.43 (5%) | 0.44 (7%) | 4.6 (39%) | |
Cerebellum | LEV | 4.8 (81%) | 8.9 (679%) | 13.8 (5%) | 0.093 (14%) | 0.41 (5%) | 0.38 (6%) | 3.4 (32%) | |
Putamen | BRV | 75.3 (86%) | 9.2 (271%) | 21.5 (6%) | 0.087 (31%) | 0.46 (6%) | 0.45 (12%) | 8.5 (40%) | |
Frontal cortex | BRV | 321.6 (99%) | 9.0 (133%) | 18.6 (6%) | 0.098 (27%) | 0.44 (7%) | 0.41 (20%) | 5.4 (37%) | |
Cerebellum | BRV | 58.9 (91%) | 10.1 (923%) | 13.9 (6%) | 0.096 (23%) | 0.37 (6%) | 0.35 (15%) | 8.8 (34%) | |
5-parameter | Putamen | LEV | 5.2 (42%) | 21.6 (4%) | 0.076 (11%) | 0.47 (3%) | 0.49 (5%) | ||
Frontal cortex | LEV | 5.1 (41%) | 18.7 (4%) | 0.088 (11%) | 0.43 (3%) | 0.43 (5%) | |||
Cerebellum | LEV | 4.0 (59%) | 13.7 (4%) | 0.099 (11%) | 0.37 (4%) | 0.36 (6%) | |||
Putamen | BRV | 88.3 (46%) | 21.5 (5%) | 0.089 (27%) | 0.46 (4%) | 0.46 (10%) | |||
Frontal cortex | BRV | 72.9 (49%) | 18.3 (5%) | 0.105 (26%) | 0.44 (4%) | 0.42 (10%) | |||
Cerebellum | BRV | 43.9 (57%) | 13.5 (5%) | 0.094 (21%) | 0.37 (4%) | 0.35 (11%) | |||