Fig. 1From: Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2ACompartment model for 11C-UCB-J and antiepileptic drugs. See Table 1 for definitions. The plasma inputs for tracer and drug (CP(t) and DP(t)) are measured and the sum of CND(t) and CS(t) is measured as the PET signal. The total SV2A concentration, Bmax, is the sum of CS(t) (divided by molar activity), Bfree(t), and DS(t)Back to article page