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Table 5 Formulas for the Infection, malignancy, and NIID prediction model

From: Diagnostic models for fever of unknown origin based on 18F-FDG PET/CT: a prospective study in China

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Formula

Infection prediction model

logit (p) = 0.92* (maximum SUVmax of spleen, bone marrow and lymph node < 5.7 = 1) + 0.78* (2.3 ≤ SUVmax of liver ratio < 4.7 = 1, SUVmax of liver ratio < 2.3 = 2) + 1.76* (maximum platelets > 132*109/L = 1) + 1.29* (minimum neutrophilic percentage < 65% or maximum neutrophilic percentage < 85% = 1) + 2.09* (ESR ≤ 96 mm/H = 1) + 1.24* (maximum LDH ≤ 340 U/L = 1) + 2.57*IGRA (positive = 1) + 3.01*ANA and ANCA (both negative = 1) + 1.03*rash (negative = 1)− 10.17

Malignancy prediction model

0.29*SUVmax + 1.89* (nasopharynx SUVmax ≥ 5.6 = 1) + 1.79* (35*109/L < platelet ≤ 170*109/L = 1, platelet < 35*109/L = 2) + 0.26*LDH/100 + 2.29* (SF < 3200 ug/L = 1) + 1.36*splenomegaly (splenic thickness ≥ 4.7 cm = 1) + 1.82* (weight loss = 1)–8.64

NIID prediction model

logit (p) = 2.73* (SUVmax of liver ratio ≤ 2.8 = 1) + 2.28* (platelet > 210*109/L = 1) + 1.9* (maximum neutrophilic percentage ≥ 85.7%, minimum neutrophilic percentage ≥ 52.5%, both positive = 2, either positive = 1) + 1.95* (SF ≥ 3200 ug/L = 1) + 4.17*ANA and ANCA (either positive = 1) + 2.4*rash (positive = 1) + 1.11*young (age ≤ 43 years = 1)−9.8

  1. NIID noninfectious inflammatory disease; SUVmax the maximum standardized uptake value; ESR erythrocyte sedimentation rate; LDH lactate dehydrogenase; IGRA interferon gamma release assay; ANA antinuclear antibody; ANCA anti-neutrophil cytoplasm antibody; SF serum ferritin