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EJNMMI Research
Fig. 7 | EJNMMI Research

Fig. 7

From: Development of a 64Cu-labeled CD4+ T cell targeting PET tracer: evaluation of CD4 specificity and its potential use in collagen-induced arthritis

Fig. 7

CD4+ T cell infiltration in arthritic joints. a Representative immunohistochemical images of CD4 infiltration in a joint with collagen-induced arthritis (CIA) (score 3; A: upper panels) and in a joint from a control mouse (A: lower panels). Mice with CIA were scored according to degree of inflammation (swelling and erythema) in each paw on a scale from 0 to 4. b Flow cytometric analysis with infiltration of CD4+ T cells and neutrophils as percent of viable cells in the carpal and tarsal joints from control, dexamethasone (DXM) treated and untreated CIA mice. Each point represents a joint. Gating strategy is shown in Additional file 1: Fig. S2. Data are presented as mean ± SEM and are pooled from two independent experiments with similar results. The significance level is indicated by asterisks (*). p < 0.01 (**), p < 0.001 (***) and p < 0.0001 (****)

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