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EJNMMI Research
Fig. 6 | EJNMMI Research

Fig. 6

From: Development of a 64Cu-labeled CD4+ T cell targeting PET tracer: evaluation of CD4 specificity and its potential use in collagen-induced arthritis

Fig. 6

[64Cu]Cu-NOTA-CD4 and [64Cu]Cu-NOTA-IgG2b PET imaging of C57BL/6 mice after whole-body irradiation (WBI) of 5 Gy. a [64Cu]Cu-NOTA-CD4 and 64Cu-isotype control uptake in the spleen of WBI (5 Gy) (n = 8/group) and non-irradiated control mice (n = 6/group) expressed as %ID/g. Images were acquired 24 h p.i. (48 h after irradiation). Spleen (S). Data are presented as mean ± SEM. The significance level is indicated by asterisks (*). p < 0.0001 (****). b Representative maximum intensity projection (coronal view) of a WBI mouse 24 h p.i. of [64Cu]Cu-NOTA-CD4, illustrating uptake in spleen (S)

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