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EJNMMI Research
Fig. 5 | EJNMMI Research

Fig. 5

From: Development of a 64Cu-labeled CD4+ T cell targeting PET tracer: evaluation of CD4 specificity and its potential use in collagen-induced arthritis

Fig. 5

Isotype control uptake on PET images of collagen-induced arthritis (CIA) mice. a [64Cu]Cu-NOTA-IgG2b imaging 24 h p.i. of the carpal and tarsal joints of control (n = 6) and CIA mice (n = 8). Tracer accumulation is calculated as %ID/joint and %Max ID/g. Each point represents a joint. b Comparison of [64Cu]Cu-NOTA-CD4 (n = 23) and isotype control, [64Cu]Cu-NOTA-IgG2b (n = 7) uptake in spleen, thymus, liver and blood of CIA mice expressed as %ID/g. Data are presented as mean ± SEM. The significance level is indicated by asterisks (*). p < 0.0001 (****)

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