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Fig. 2 | EJNMMI Research

Fig. 2

From: Development of a 64Cu-labeled CD4+ T cell targeting PET tracer: evaluation of CD4 specificity and its potential use in collagen-induced arthritis

Fig. 2

Characterization of the collagen-induced arthritis (CIA) mouse model and [64Cu]Cu-NOTA-CD4 uptake in joints. a CIA mice were scored according to degree of inflammation (swelling and erythema) in each paw on a scale from 0 to 4 (n = 6). Data are shown as mean CIA score per mouse starting on day 26 after immunization to the last day of PET/CT imaging where the mice were euthanized (day 35). Each line represents the development of arthritis in one mouse. b Representative images of a CIA mouse on day 35 with pronounced arthritis in right carpal and tarsal joints. c [64Cu]Cu-NOTA-CD4 uptake per joint (%ID/joint) and maximum activity (%Max ID/g) in carpal and tarsal joints of CIA mice (n = 6) and control mice (n = 4) at 1, 4, 24 and 44 h p.i. Asterisks (*) represent statistical significance between controls and mice with high CIA score (score 3). Data are presented as mean ± SEM. (*). p < 0.01 (**), p < 0.001 (***) and p < 0.0001 (****). d Representative maximum intensity projections (coronal view) of a CIA mouse with pronounced arthritis (score 3) in left carpal and right tarsal joint at 1, 4, 24 and 44 h p.i. of [64Cu]Cu-NOTA-CD4. White arrows indicate lesion sites with score 3

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