Short-time-window Patlak imaging using a population-based arterial input function and optimized Bayesian penalized likelihood reconstruction: a feasibility study

EJNMMI Research

Table 2 Each Ki parameter value and correlations of Ki parameter values in individual patient-based and population-based Ki images of 51 positive scans

	Reader 1	Reader 2
Individual patient-based Ki image	Mean ± SD (range)	Mean ± SD (range)
Ki-max (× 10⁻³)^a	149.5 ± 116.3 (47.4–545.4)	153.6 ± 120.3 (47.4–552.0)
Ki-mean (× 10⁻³)^a	83.8 ± 70.1 (27.0–333.0)	85.0 ± 71.4 (25.8–326.4)
Ki-volume^b	56.0 ± 29.0 (2.4–118.0)	59.7 ± 28.5 (2.4–115.0)

Population-based Ki image	Mean ± SD (range)	Linear regression^c			Mean ± SD (range)	Linear regression^c
Population-based Ki image	Mean ± SD (range)	r	r²	p	Mean ± SD (range)	r	r²	p
Ki-350 images
Ki-max (× 10⁻³)^a	245.5 ± 149.9 (88.2–701.4)	0.93	0.86	< 0.001	278.6 ± 157.4 (88.2–701.4)	0.90	0.80	< 0.001
Ki-mean (× 10⁻³)^a	128.9 ± 85.0 (46.2–403.2)	0.91	0.83	< 0.001	132.2 ± 82.6 (46.2–404.4)	0.89	0.79	< 0.001
Ki-volume^b	31.4 ± 19.6 (1.1–84.5)	0.84	0.70	< 0.001	30.9 ± 18.8 (1.1–82.8)	0.75	0.57	< 0.001
Ki-700 images
Ki-max (× 10⁻³)^a	228.1 ± 142.6 (76.2–671.4)	0.94	0.89	< 0.001	242.2 ± 138.9 (82.2–672.0)	0.94	0.88	< 0.001
Ki-mean (× 10⁻³)^a	121.4 ± 90.0 (39.6–392.4)	0.94	0.88	< 0.001	124.4 ± 80.8 (40.8–394.8)	0.95	0.89	< 0.001
Ki-volume^b	30.0 ± 21.3 (1.4–94.3)	0.82	0.67	< 0.001	38.7 ± 22.4 (1.4–91.6)	0.73	0.54	< 0.001
Ki-1000 images
Ki-max (× 10⁻³)^a	206.7 ± 140.0 (64.8–654.6)	0.95	0.91	< 0.001	219.5 ± 136.8 (64.8–654.0)	0.96	0.92	< 0.001
Ki-mean (× 10⁻³)^a	110.8 ± 79.7 (33.6–384.6)	0.95	0.91	< 0.001	113.7 ± 79.8 (33.6–387.0)	0.96	0.92	< 0.001
Ki-volume^b	41.8 ± 23.3 (1.7–96.0)	0.87	0.75	< 0.001	41.3 ± 22.6 (1.8–95.4)	0.78	0.60	< 0.001

SD, Standard deviation; Ki-max, Maximum Ki; Ki-mean, Mean Ki; Ki-volume, Volume of Ki; r, Correlation coefficient; and r², Coefficient of determination
^aThe unit of Ki-max and Ki-mean is ml/g/min
^bThe unit of Ki-volume is cm³
^cThe linear regression between the patient-based Ki image and the population-based Ki images