Fig. 4
From: PARP targeted Auger emitter therapy with [125I]PARPi-01 for triple-negative breast cancer
A TUNEL staining of 6 µm thick tumour tissues obtained post sacrifice show high apoptosis (green) in [125I]PARPi-01 treated tumour tissues as opposed to untreated tumour tissues. B Anti-PARP1 staining of target tissue (tumour) and non-target tissue (Liver and Thyroid) showed a nuclear expression of PARP1 only in tumour. Negative control without primary antibody shows no unspecific signal. C Quantification of percentage of apoptosis positive nuclei showed that [125I]PARPi-01 had significantly high (unpaired t-test; p < 0.05) apoptotic nuclei than untreated tumour tissue