[18F]FE-PE2I PET is a feasible alternative to [123I]FP-CIT SPECT for dopamine transporter imaging in clinically uncertain parkinsonism

EJNMMI Research

Table 1 Comparison between the two clinical setups/workflows

	[¹²³I]FP-CIT SPECT	[¹⁸F]FE-PE2I PET (30–40-min protocol)
Half-life of tracer (transport logistics)	13 h 13 min	1 h 50 min
Patient time	4 h 15 min	1 h 30 min
Time in scanner	30 min	15 min
Staff time	1 h 50 min	1 h 15 min
Scanner	Short moving bore	Long narrow bore
Pretreatment to block thyroid ¹²³I uptake	Yes	No
Radiation exposure*	185 MBq / 4.6 mSv	185 MBq /4.3 mSv
Sensitivity to SSRI treatment	Yes [38]	Insignificant [11]
Approximate spatial resolution	10 mm	5 mm

SSRI selective serotonin reuptake inhibitors
Time estimates are based on logistics in our high throughput clinic with 20–30 patients/week
*Based on an effective dose of 0.025 mSv/MBq for [¹²³I]FP-CIT[38] and 0.023 mSv/MBq for [¹⁸F]FE-PE2I[44]