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Table 1 Kinetic parameters and total distribution volume (VT) values estimated with the one-tissue compartment model (1TCM), along with VT values estimated using two-tissue compartment model (2TCM), and Logan analysis for 11C-CPPC PET imaging in humans (N = 8)

From: First-in-human use of 11C-CPPC with positron emission tomography for imaging the macrophage colony-stimulating factor 1 receptor

Region of interest

1TCM

2TCM

Logan

K1

k2

VT

VT

VT

(mL cm−3 min−1)

(min−1)

(mL cm−3)

(mL cm−3)

(mL cm−3)

Thalamus

0.29 ± 0.04 (0.97)

0.02 ± 0.00 (1.99)

16.6 ± 2.0 (1.34)

16.9 ± 2.1 (1.92)

16.0 ± 2.0 (1.26)

Striatum

0.30 ± 0.04 (0.96)

0.02 ± 0.00 (1.94)

16.2 ± 1.8 (1.30)

16.3 ± 1.9 (3.11)

15.2 ± 1.8 (1.28)

Parietal cortex

0.32 ± 0.03 (0.80)

0.02 ± 0.00 (1.54)

16.1 ± 1.7 (1.02)

16.2 ± 1.7 (1.85)

15.2 ± 1.5 (0.70)

Cingulate cortex

0.31 ± 0.04 (0.92)

0.02 ± 0.00 (1.78)

15.7 ± 2.0 (1.18)

15.8 ± 2.0 (2.68)

14.9 ± 1.9 (1.09)

Temporal cortex

0.26 ± 0.03 (0.92)

0.02 ± 0.00 (1.96)

15.6 ± 1.8 (1.33)

15.7 ± 1.8 (3.04)

14.7 ± 1.6 (1.10)

Frontal cortex

0.32 ± 0.04 (0.85)

0.02 ± 0.00 (1.60)

15.2 ± 1.5 (1.06)

15.3 ± 1.5 (1.31)

14.5 ± 1.5 (0.92)

Occipital cortex

0.31 ± 0.02 (0.90)

0.02 ± 0.00 (1.71)

14.9 ± 1.7 (1.13)

15.0 ± 1.7 (1.92)

14.1 ± 1.5 (0.65)

Hippocampus

0.22 ± 0.02 (1.23)

0.02 ± 0.00 (2.64)

14.1 ± 1.8 (1.80)

14.4 ± 1.8 (2.01)

13.6 ± 1.6 (2.48)

Cerebellar cortex

0.29 ± 0.04 (0.85)

0.02 ± 0.00 (1.58)

13.9 ± 1.4 (1.05)

14.0 ± 1.4 (1.76)

13.2 ± 1.4 (0.61)

Total white matter

0.21 ± 0.02 (1.05)

0.04 ± 0.06 (2.28)

13.6 ± 1.8 (1.55)

14.0 ± 2.0 (1.55)*

13.5 ± 1.8 (1.20)

  1. Presented as Mean ± standard deviation, and mean percent standard error in parentheses
  2. *One individual had poor fit for data from total white matter. The white matter data from this individual were excluded from the reported mean VT for this region