Fig. 1

A Average voxel-wise maps of baseline and follow-up.¹⁸F-Flutemetamol PET uptake ratios (warmer colors represent higher uptake ratios) in patients with amyloid-positive (N = 15/10) and amyloid-negative (N = 19/15) baseline scans. Patients with amyloid-positive baseline scans showed increased cortical 18F-Flutemetamol uptake. In contrast, in patients with amyloid-negative baseline scans, negligible 18F-Flutemetamol uptake was seen in gray matter at baseline or follow-up. B Voxel-wise statistical mapping was conducted to assess longitudinal change. Widespread clusters of positive change were observed in amyloid-positive (top panel), but not in amyloid-negative patients (bottom panel). Statistical parametric maps are expressed in T-values using a threshold T ≥ 2.5 (cluster-forming threshold zero), corresponding to approximately p < 0.01 (uncorrected)