Optimal imaging time points considering accuracy and precision of Patlak linearization for 89Zr-immuno-PET: a simulation study

EJNMMI Research

Table 2 Smallest and largest percentage bias and variability of simulations with and without time point 24 h p.i. for both K_i and V_T

	With 24 h		Without 24 h		With 24 h		Without 24 h
	K_i				V_T
	Smallest	Largest	Smallest	Largest	Smallest	Largest	Smallest	Largest
Bias (%)
⁸⁹Zr-huJ591	− 6.2	− 16.2	− 12.5	− 24.9	− 7.0	7.0	− 9.3	− 46.7
⁸⁹Zr-trastuzumab	− 2.7	− 10.0	− 2.9	− 8.1	− 2.2	3.2	− 11.2	− 55.4
⁸⁹Zr-pertuzumab	− 1.5	− 5.0	− 2.0	− 6.4	− 3.0	0.8	− 8.4	− 36.0
Variability (%)
⁸⁹Zr-huJ591	9.2	11.1	9.9	10.9	16.3	57.4	43.6	127.6
⁸⁹Zr-trastuzumab	7.2	10.7	9.6	16.4	14.6	22.2	32.3	92.8
⁸⁹Zr-pertuzumab	7.4	10.5	9.1	13.9	13.2	20.5	28.3	71.6