Fig. 2
Patlak linearization for 89Zr-pertuzumab input function and time activity curves with 5% noise, rKi = 1·10−3 [h−1], rVT = 0.2 and time points 24, 48 and 96 h post-injection. A: Activity concentrations in plasma (red) and tissue (blue), full curve based on reference values (rACp and rACt) and calculated based on simulations (sACp and sACt) in percentage injected activity per liter as a function of time p.i. B: Patlak plot; activity concentration in tissue (ACt) divided by activity concentration in plasma (ACp) as a function of area under the plasma curve (AUCp) divided by activity concentration in plasma (ACp). Based on reference values (black), simulated values (green) and linear regression of the simulated values (pink). %IA/L = percentage injected activity per liter