Fig. 7

Trk inhibitory effect in BAT tissue. A Representative PET images as sagittal projection after 30 min post-injection of 5–7 MBq [¹⁸F]TRACK into a wild-type (WT) control mouse in the absence (left) or presence of 5 mg/kg entrectinib (right). B Effects of 0.1 (n = 3) and 0.5 mg/kg (n = 2) TRACK (co-injected with the radiotracer iv) on the time–activity curve (TAC) of [¹⁸F]TRACK (n = 3) in BAT tissue. C Effect of 5 mg/kg (n = 3) entrectinib (pre-injected 15 min before the radiotracer i.p.) on the time–activity curve (TAC) of [¹⁸F]TRACK (n = 3) in BAT tissue. B–C Data are shown as mean ± SEM from n experiments