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Fig. 6 | EJNMMI Research

Fig. 6

From: [18F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer’s disease pathology in APP/PS1 mice

Fig. 6

Oxidative damage is highest in the female APP/PS1 at advanced age. a Representative confocal images showing increased oxidative damage in neurons (NeuN; red) of APP/PS1 mice detected by 3-nitrotyrosine (3NT; green) adducts in the cortex at 16 mo. of age. Scale bar = 50 µm. b Quantification of 3NT-positive cells in the cortex of age-matched WT and APP/PS1 mouse brain tissues, n = 4 per group. The statistical significance of p value calculated by one-way ANOVA. Values represent mean ± SEM, *p < 0.05, **p < 0.005, ****p < 0.0001

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