Skip to main content
Fig. 1 | EJNMMI Research

Fig. 1

From: [18F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer’s disease pathology in APP/PS1 mice

Fig. 1

Validation of the plateau phase and pseudo-reference region for ox[18F]ROStrace PET analysis. a The chemical structures of [18F]ROStrace and [18F]ox-ROStrace. Comparison of b body weight (g) and c periaqueductal gray (PAG) SUV from 40–60 min. 5 mo. old: APP/PS1 group: n = 6 for female, and n = 9 for male; WT group: n = 9 per gender,10 mo. old: APP/PS1 group: n = 4 per gender; WT group: n = 6 per gender, and 16 mo. old: APP/PS1 group: n = 6 for female, and n = 12 for male; WT group: n = 10 per gender. The statistical significance of p value calculated by two-way ANOVA: ****p < 0.0001, ***p < 0.001, *p < 0.05. Micro-PET data analysis validates that oxidative stress, not blood flow, contributes the [18F]ROStrace signals in the animal brain. Time–activity curves in SUV of whole brain d in WT female (n = 5), WT male (n = 5), APP/PS1 female (n = 4), and APP/PS1 male (n = 5) mice at 16 mo. of age. Data are shown as mean ± standard deviation. Comparison of the average [18F]ROStrace SUVR from 9 VOIs at 16-mo.-old animals in e perfusion phase (1–3 min) and plateau phase (40–60 min). (WT groups: n = 5 per gender, and APP/PS1 group: n = 4 for female, and n = 5 for male) The statistical significance of p value calculated by one-way ANOVA (*p < 0.05)

Back to article page