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EJNMMI Research
Fig. 1 | EJNMMI Research

Fig. 1

From: Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model

Fig. 1

[11C]MPC-6827 a standard cell uptake b tubulin kit-based assay in vitro with different MT stabilizing and destabilizing agents after 30 min incubation (n = 6/group), using in SH-SY5Y cells; *p ≤ 0.05, **p = 0.004, ***p = 0.00014; c representative axial and sagittal PET/CT brain images from FVB/B6 wild type mice (n = 4) at baseline and after EpoD treatment with d their whole-brain SUVmax after IV injection of [11C]MPC-6827 (3.7 ± 0.05 MBq); *p ≤ 0.05, **p = 0.0061

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