Table 4 Literature overview of [68Ga]Ga-peptide PET/CT in pulmonary carcinoid tumours (PCs) (case reports excluded)
Author | Year | n | [68Ga]Ga-peptide | Main results |
|---|---|---|---|---|
Kumar [41] | 2009 | 7 | -DOTATOC | TCs had mild [18F]FDG uptake and high [68Ga]Ga-DOTATOC uptake. ACs had moderate uptake of [18F]FDG and high [68Ga]Ga-DOTATOC uptake. The combined use of [18F]FDG and [68Ga]Ga-DOTATOC PET/CT reveals different uptake patterns in various bronchial tumours |
Ambrosini [24] | 2009 | 11 | -DOTANOC | [68Ga]Ga-DOTANOC PET/CT provided additional information in 9 of 11 patients compared to conventional imaging, leading to changes in the clinical management of 3 of these 9 patients |
Kayani [39] | 2009 | 18 | -DOTATATE | Typical bronchial carcinoids showed higher and more selective uptake of [68Ga]Ga-DOTATATE than of [18F]FDG. Atypical carcinoids and higher grades had less [68Ga]Ga-DOTATATE avidity but were [18F]FDG-avid |
Jindal [43] | 2011 | 20 | -DOTATOC | TCs had a lower [18F]FDG and a higher [68Ga]Ga-DOTATOC uptake compared with ACs. The ratio of SUVmax on [68Ga]Ga-DOTATOC and on [18F]FDG PET/CT was a better predictor of the histopathologic variety of the PC compared with the SUVmax on the 2 types of scans individually |
Venkitaraman [44] | 2014 | 32 | -DOTATOC | [68Ga]Ga-DOTATOC has a high sensitivity, specificity and accuracy in the detection of PC, whereas [18F]FDG PET/CT suffers from a low sensitivity and specificity in differentiating PCs from other tumours |
Lococo [10] | 2015 | 33 | -DOTATOC -DOTATATE -DOTANOC | [68Ga]Ga-DOTA-peptide PET/CT was superior in detecting TC whereas [18F]FDG PET/CT was superior in detecting AC. The SUVmax ratio was the most accurate semiquantitative index in identifying TC |
Prasad [49] | 2015 | 27 | -DOTATOC -DOTATATE | It is necessary to combine functional ([68Ga]Ga-SSR PET) and morphological imaging in the restaging of patients with TC and AC. The major advantage of [68Ga]Ga-SSR PET lies in the detection of additional bone lesions |
Lococo [45] | 2019 | 26 | -DOTATOC | In the detection of PCs, [68Ga]Ga-DOTATOC PET ensures better diagnostic performance compared to [18F]FDG PET. [68Ga]Ga-DOTATOC performs at its best in TCs, and [18F]FDG in ACs. [68Ga]Ga-DOTATOC uptake was negatively correlated with the number of mitoses and the presence of necrosis |
Komek [46] | 2019 | 20 | -DOTATATE | SUVmax values were higher for atypical PC on [18F]FDG PET and for typical PC on [68Ga]Ga-DOTATATE PET, indicating the potential utility of the SUVmax ratio in predicting the histological subtype of PC tumours |
Purandare [11] | 2020 | 119 | -DOTANOC | [68Ga]Ga-DOTANOC PET/CT is highly sensitive in detecting PC and detects asymptomatic distant metastatic disease in a sizeable number of patients (11.7%), thus contributing to clinical management. TCs show significantly higher uptake than ACs. [68Ga]Ga-DOTA-peptide PET/CT should be an integral part of the diagnostic work-up of patients with PC |
Deleu (this series) | 2022 | 86 | -DOTATOC -DOTATATE | The role of PET/CT in the assessment of the tumour biology of PC was confirmed based on a significantly higher SSTR ligand and lower [18F]FDG uptake in TC compared to AC. Moreover, a high sensitivity of 80% of SSTR PET/CT in detecting regional lymph node metastases was found. Finally, SSTR PET/CT has a PPV of 100% in a small sub-cohort of patients with pathologically examined distant metastases |