Fig. 2

Examples of MRI and FBY PET images in circumscribed tumors. A left temporal-occipital metastatic breast cancer (HER2 positive, ER and PR negative) revealed significant contrast enhancement (A) and FBY activity (B), with better adhesion between the two regions (C). Semiautomated segmentation based on MRI (D) and FBY PET (E) was performed, and minimum FBY activity beyond MRI contrast enhancement was noted (F). Similarly, a right temporal-occipital metastatic breast cancer (HER2 negative, ER and PR positive) displayed contrast enhancement (G) and FBY uptake of the whole tumor region (H), both of which presented an explicit tumor extent (I). The semiautomated segmentations (J, K) were also largely equivalent (L), which may be due to the clear boundary of circumscribed tumors