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Table 1 Extrapolated human dosimetry for [111In]CHX-DTPA-scFv78-Fc

From: Comparison of absorbed dose extrapolation methods for mouse-to-human translation of radiolabelled macromolecules

[111In]CHX-DTPA-scFv78-Fc

Average human AD extrapolations (mGy/MBq) (GA Subject)

Target organ

M1

M2*

M3

M4

M5

Adrenals

4.34E−01

3.15E−01

5.12E−01

3.57E−01

2.07E−01

Brain

1.73E−02

2.43E−02

2.88E−02

4.17E−02

5.91E−02

Breasts

5.01E−02

4.09E−02

6.15E−02

6.73E−02

6.77E−02

Oesophagus

1.56E−01

1.10E−01

1.74E−01

1.45E−01

1.14E−01

Eyes

1.75E−02

2.44E−02

2.90E−02

4.19E−02

5.92E−02

Gallbladder Wall

3.76E−01

2.20E−01

4.09E−01

2.43E−01

2.19E−01

Left colon

2.78E−01

1.07E−01

4.06E−01

1.55E−01

1.01E−01

Small Intestine

5.68E−01

1.55E−01

6.58E−01

1.91E−01

9.98E−02

Stomach Wall

2.38E−01

1.30E−01

2.63E−01

1.56E−01

1.12E−01

Right colon

3.06E−01

1.13E−01

4.54E−01

1.53E−01

1.20E−01

Rectum

2.29E−01

6.61E−02

3.60E−01

1.35E−01

8.60E−02

Heart wall

2.31E−01

1.28E−01

2.80E−01

2.65E−01

1.15E−01

Kidneys

5.77E−01

2.98E−01

9.63E−01

4.58E−01

2.23E−01

Liver

9.23E−01

5.70E−01

8.87E−01

5.68E−01

5.02E−01

Lungs

1.33E−01

1.29E−01

1.78E−01

1.79E−01

1.07E−01

Ovaries

7.31E−01

1.42E−01

7.66E−01

7.14E−01

9.82E−02

Pancreas

3.43E−01

1.82E−01

3.78E−01

2.07E−01

1.57E−01

Prostate

6.29E−02

4.37E−02

9.16E−02

6.30E−02

7.74E−02

Salivary glands

2.15E−02

2.87E−02

3.37E−02

4.77E−02

6.66E−02

Red Marrow

7.28E−02

6.73E−02

1.36E−01

1.23E−01

7.89E−02

Osteogenic cells

8.60E−02

7.58E−02

1.36E−01

1.29E−01

1.20E−01

Spleen

7.14E−01

8.76E−01

7.59E−01

8.84E−01

9.71E−02

Testes

1.88E−02

2.56E−02

2.90E−02

3.82E−02

5.72E−02

Thymus

8.46E−02

6.78E−02

1.05E−01

1.12E−01

8.81E−02

Thyroid

3.88E−02

4.26E−02

5.49E−02

6.58E−02

7.21E−02

Urinary bladder wall

7.62E−02

4.20E−02

1.02E−01

8.27E−02

8.07E−02

Uterus

9.07E−01

1.65E−01

9.53E−01

8.62E−01

9.60E−02

Total body

7.99E−02

5.82E−02

1.01E−01

8.39E−02

8.30E−02

Effective dose (mSv/MBq)

1.96E−01

1.16E−01

2.41E−01

1.64E−01

1.05E−01

  1. Mouse-to-human dose extrapolations were based on time-integrated activity coefficients (TIACs) obtained from biodistribution data on mice, reported in [24]. Human TIACs were calculated for male and female subjects with five different computational methods and used as input in OLINDA/EXM v.2.1 to derive gender average (GA) organ absorbed doses (ADs) and effective doses (ED) according to the ICRP-103 [32]
  2. *Extrapolations according to M2 were already reported in Table 2 of [24]
  3. Indicates source organs