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Fig. 3 | EJNMMI Research

Fig. 3

From: The sodium iodide symporter (NIS) as theranostic gene: its emerging role in new imaging modalities and non-viral gene therapy

Fig. 3

NIS-mediated in vivo small-animal PET imaging of U87-NIS brain tumors. Comparison of U87-NIS brain tumor detection by [124I]NaI- and [18F]TFB-PET. a, c Sagittal and coronal planes of [18F]TFB-PET and [124I]NaI-PET/CT scans are displayed. The brain areas are circled in white and tumoral tracer uptake was seen for both radionuclides (arrows). Low level of bone accumulation indicate a minimal level of residual free fluoride. b, d Quantification of serial PET imaging representing the efflux of tumoral 124I and an increase of [18F]TFB in the tumor (n = 5 each). Representative pictures show sectional planes of the 1 h time point after i.v. tracer injection (10 MBq). Results are expressed as mean ± SEM

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