Fig. 2

NIS-mediated in vivo imaging of mice bearing subcutaneous U87-NIS tumors. a Planar gamma camera imaging showed NIS-specific tumoral ¹²³I uptake of 9.4% ID/g tumor (n = 2; + NaClO₄ n = 1) 1 h after intraperitoneal application of 18.5 MBq [¹²³I]NaI. b PET scans revealed 4.8 ± 1.1% ID/mL ¹²⁴I accumulation in the tumor (n = 5; + NaClO₄ n = 3). c [¹⁸F]TFB-PET scans resulted in a maximum tumoral [¹⁸F]TFB accumulation of 7.1% ID/mL (n = 1, + NaClO₄ n = 1). Presented PET images show sectional planes (coronal orientation) 1 h after i.v. tracer injection of 10 MBq. Tracer uptake of the tumors was blocked upon treatment with the NIS-specific inhibitor perchlorate. Tumors are circled in red; sg, salivary glands