Target occupancy study and whole-body dosimetry with a MAGL PET ligand [11C]PF-06809247 in non-human primates

EJNMMI Research

Table 2 Kinetic parameters and K_i by 2TC and Patlak slope

	K₁ (ml/ccm/min)		k₂ (1/min)		k₃ (1/min)		2TC K_i (ml/ccm/min)		Patlak slope (ml/ccm/min)
	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
cer	0.849	0.361	0.645	0.392	0.750	0.373	0.461	0.142	0.425	0.119
cau	0.710	0.313	0.655	0.535	1.335	0.871	0.471	0.110	0.444	0.098
put	0.899	0.547	0.780	0.731	1.287	0.524	0.550	0.166	0.512	0.147
tha	0.643	0.215	0.441	0.344	0.824	0.444	0.430	0.092	0.413	0.073
fro	0.498	0.177	0.265	0.235	0.883	0.640	0.388	0.096	0.371	0.090
tem	0.551	0.220	0.308	0.282	0.782	0.483	0.403	0.098	0.384	0.089
hip	0.621	0.179	0.475	0.413	0.717	0.437	0.393	0.082	0.371	0.075

cer cerebellum, cau caudate, put putamen, tha thalamus, fro frontal cortex, tem temporal cortex, hip hippocampus, SD standard deviation, 2TC two-tissue compartment model