Fig. 1
From: Initial evaluation of [18F]-FACBC for PET imaging of multiple myeloma
Preclinical comparison of [18F]-FET versus [18F]-FACBC in MM. A Structure of the radiotracers [18F]-FET and [18F]-FACBC together with a representative axial section and a maximum intensity projection (MIP) of the shoulder region. For both radiotracers, eight animals were injected with MM.1S cells transduced with control (ev/ev, blue arrowheads, left shoulder) and LAT1/CD98hc transduced (MM.1SLAT1/CD98hc, green arrowheads, right shoulder). B From 8 mice injected per cohort, 5–8 xenograft tumors had grown, which were imaged and segmented. Student’s t-test with *p < 0.05; **p < 0.01; ***p < 0.005, error bars indicate SD. C Dynamic [18F]-FACBC PET-scan of a mouse with 10 min frames over 50 min post injection represented as a MIP. D [18F]-FACBC time-activity curve for different tissues measured by a representative sphere with 5 px diameter, error bars indicate SD