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Fig. 4 | EJNMMI Research

Fig. 4

From: CXCR4 peptide-based fluorescence endoscopy in a mouse model of Barrett’s esophagus

Fig. 4

Dysplastic lesions of IL1B mice detected by fluorescence endoscopy and MK007. A Representative endoscopy images of two MK007-injected IL1B mice (60 nmol; 4 h p.i.), 14 and 12 months old (left) and two negative controls, 17 and 12 months old (right). Two endoscopy frames per each mouse are showed: visible dysplastic lesions in the color channel (red arrows) corresponded with the presence of Sulfo-Cy5 signal (red line). No Sulfo-Cy5 signal was detected in negative controls, despite visible lesions were found in both mice (black arrows). Fluorescence images are showed in grey scale. C Endoscopy images (left) and ex vivo wide-field imaging (right, up) of the third injected mouse, 14 months old. The ex vivo imaging of the other two injected mice is showed in Fig. 2A. Sulfo-Cy5 signal observed by endoscopy is indicated by the red line. A high Sulfo-Cy5 signal in the SCJ (blue line) was further confirmed by ex vivo imaging of the whole stomach. Quantification of Sulfo-Cy5 signal from all lesions in injected mice showed a significantly higher TBR than lesions in negative controls. Two to five dysplastic lesions were evaluated per each mouse. The signal quantification was performed as described in the Methods section. Data are represented as the TBR of each evaluated lesion and mean value ± SEM. **P < 0.01 by unpaired two-tailed T test

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