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Table 1 Time-integral of activity for accumulation in significant source organs (AUCs)

From: Preclinical biodistribution and dosimetry and human biodistribution comparing 18F-rhPSMA-7 and single isomer 18F-rhPSMA-7.3

 

AUC (%IA/g) organ

Heart

Lung

Liver

Spleen

Kidney

18F-rhPSMA-7

No extrapolation

0.17 ± 0.01

0.84 ± 0.04

0.78 ± 0.05

1.93 ± 0.13

6.39 ± 0.65

 

Extrapolation + physical decay

0.18 ± 0.01

0.9 ± 0.04

0.87 ± 0.06

2.1 ± 0.13

10.12 ± 0.75

18F-rhPSMA-7.3

No extrapolation

0.29 ± 0.03

1.35 ± 0.12

1.25 ± 0.08

2.05 ± 0.2

8.99 ± 0.64

 

Extrapolation + physical decay

0.3 ± 0.03

1.38 ± 0.12

1.33 ± 0.08

2.08 ± 0.2

10.8 ± 0.74

  1. AUC: area under the curve; %IA: %injected activity. AUC is presented ± standard deviation