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Table 4 Summary of the fraction of hypoxic voxels at baseline (‘pre’) and pre-surgery (‘post’) visits for atovaquone-treated patients, with four-hour hypoxia PET-CT. Three TBR categories were used to define progressively higher hypoxia PET tracer uptake: 1.4 ≤ TBR < 1.6 (a), 1.6 ≤ TBR < 1.8 (b), and TBR ≥ 1.8 (c). Mean values and IQR are shown for pre and post with P values for the difference pre to post

From: Investigation of atovaquone-induced spatial changes in tumour hypoxia assessed by hypoxia PET/CT in non-small cell lung cancer patients

  Overall Centre Inner Outer Edge
Pre Post Pre Post Pre Post Pre Post Pre Post
(a)
 Mean 8.8% 6.8% 9.2% 7.2% 11.2% 10.9% 12.6% 12.5% 2.1% 2.9%
 IQR 3.8–12.4% 0.0–13.9% 6.1–13.4% 0.0–12.0% 8.6–13.7% 4.2–17.1% 9.2–15.4% 8.0–17.0% 0.0–3.4% 0.0–5.4%
 P 0.96 0.31 0.95 0.91 0.21
(b)
 Mean 6.1% 4.7% 5.0% 4.7% 9.2% 6.7% 8.7% 6.4% 1.5% 1.3%
 IQR 0.0–9.5% 0.0–8.6% 0.0–6.9% 0.0–7.9% 5.1–12.8% 0.7–10.4% 3.0–12.1% 1.5–11.8% 0.0–1.5% 0.0–2.3%
 P 0.01 0.72 0.96 0.13 0.60
(c)
 Mean 11.3% 7.2% 9.6% 6.9% 16.3% 9.6% 16.9% 11.4% 2.2% 0.8%
 IQR 0.0–19.3% 0.0–4.6% 0.0–14.5% 0.0–7.7% 0.9–31.0% 0.0–8.0% 1.2–26.8% 0.0–7.7% 0.0–2.1% 0.0–0.0%
 P  < 0.001 0.11 0.009 0.01 0.27