Table 4 Summary of the fraction of hypoxic voxels at baseline (‘pre’) and pre-surgery (‘post’) visits for atovaquone-treated patients, with four-hour hypoxia PET-CT. Three TBR categories were used to define progressively higher hypoxia PET tracer uptake: 1.4 ≤ TBR < 1.6 (a), 1.6 ≤ TBR < 1.8 (b), and TBR ≥ 1.8 (c). Mean values and IQR are shown for pre and post with P values for the difference pre to post

(a)

 Mean

8.8%

6.8%

9.2%

7.2%

11.2%

10.9%

12.6%

12.5%

2.1%

2.9%

 IQR

3.8–12.4%

0.0–13.9%

6.1–13.4%

0.0–12.0%

8.6–13.7%

4.2–17.1%

9.2–15.4%

8.0–17.0%

0.0–3.4%

0.0–5.4%

 P

0.96

0.31

0.95

0.91

0.21

(b)

 Mean

6.1%

4.7%

5.0%

4.7%

9.2%

6.7%

8.7%

6.4%

1.5%

1.3%

 IQR

0.0–9.5%

0.0–8.6%

0.0–6.9%

0.0–7.9%

5.1–12.8%

0.7–10.4%

3.0–12.1%

1.5–11.8%

0.0–1.5%

0.0–2.3%

 P

0.01

0.72

0.96

0.13

0.60

(c)

 Mean

11.3%

7.2%

9.6%

6.9%

16.3%

9.6%

16.9%

11.4%

2.2%

0.8%

 IQR

0.0–19.3%

0.0–4.6%

0.0–14.5%

0.0–7.7%

0.9–31.0%

0.0–8.0%

1.2–26.8%

0.0–7.7%

0.0–2.1%

0.0–0.0%

 P

 < 0.001

0.11

0.009

0.01

0.27