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Table 3 Summary of the fraction of hypoxic voxels at baseline (‘pre’) and pre-surgery (‘post’) visits for atovaquone-treated (a) and untreated (b) patients overall and in tumour subregions, using four-hour hypoxia PET-CT analysis. Voxels with a TBR ≥ 1.4 were defined as hypoxic. Mean values and IQR are shown for pre and post with P values for the difference pre to post

From: Investigation of atovaquone-induced spatial changes in tumour hypoxia assessed by hypoxia PET/CT in non-small cell lung cancer patients

  Overall Centre Inner Outer Edge
Pre Post Pre Post Pre Post Pre Post Pre Post
(a)
 Mean 26.1% 20.3% 23.9% 18.8% 36.7% 27.2% 38.2% 30.2% 5.8% 5.1%
 IQR 4.4–45.8% 0.0–33.5% 7.7–37.1% 0.0–35.4% 17.3–60.4% 4.8–44.2% 14.3–57.1% 11.4–42.3% 0.0–8.2% 0.0–7.6%
 P  < 0.001 0.05 0.01 0.01 0.86
(b)
 Mean 23.2% 23.0% 6.2% 6.4% 10.0% 9.5% 10.6% 11.2% 4.1% 4.2%
 IQR 0.0–43.9% 0.0–42.1% 0.0–35.5% 0.0–35.6% 8.0–51.4% 9.1–44.5% 13.9–54.4% 20.4–49.0% 0.0–14.61% 0.0–24.5%
 P 0.63 0.72 0.47 0.53 0.82