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Table 3 Association of ISUP grade (n = 189), PSA level (n = 194) and ADT (n = 14) with the presence/absence of metastatic disease

From: Risk of metastatic disease using [18F]PSMA-1007 PET/CT for primary prostate cancer staging

  No metastasis Metastasis present Univariable modela Multivariable modela (n = 189)
Unadjusted OR (95%CI) p-value Adjusted OR (95%CI) p-value
n = 128 n = 66
Age (years), mean (SD) 68.9 (7.5) 69.9 (8.6) 1.02 (0.98,1.06) 0.39   
ISUP Grade     0.014   0.008
ISUP 1 88% (7/8) 13% (1/8) 0.42 (0.05,3.62)   0.32 (0.03,3.00)  
ISUP 2 and 3 75% (68/91) 25% (23/91) (reference)   (reference)  
ISUP 4 and 5 57% (51/90) 43% (39/90) 2.26 (1.20,4.25)*   2.64 (1.34,5.23)**  
PSA levels (ng/mL)     0.004   0.001
\(\le\) 10 71.3% (72/101) 28.7% (29/101) (reference)   (reference)  
10–20 74.0% (37/50) 26.0% (13/50) 0.87 (0.41,1.87)   0.93 (0.42,2.07)  
 > 20 44.2% (19/43) 55.8% (24/43) 3.14 (1.50,6.58)**   4.33 (1.89,9.91)***  
Previous or current ADT use     0.198   0.198
No 67.2% (121/180) 32.8% (59/180) (reference)   (reference)  
Yes 50.0% (7/14) 50.0% (7/14) 2.05 (0.69,6.12)   2.16 (0.67,6.96)  
  1. *p < 0.05; **p < 0.01; ***p < 0.001
  2. abinary logistic regression