Magnetic nanoparticles in theranostics of malignant melanoma

Shevtsov, Maxim; Kaesler, Susanne; Posch, Christian; Multhoff, Gabriele; Biedermann, Tilo

doi:10.1186/s13550-021-00868-6

EJNMMI Research

Table 2 Clinical trials using nanoparticles with melanoma patients

From: Magnetic nanoparticles in theranostics of malignant melanoma

Clinical trial no.	Phase	Patients	Study design	Status	Purpose	Refs
NCT00626405	II	Unresectable stage IV melanoma	Bevacizumab + Temozolomide vs Bevacizumab + paclitaxel albumin-stabilized nanoparticle formulation + carboplatin	Completed	Treatment	[100]
NCT00081042	II	Unresectable stage IV melanoma	Paclitaxel albumin-stabilized nanoparticle formulation; previously chemotherapy vs chemotherapy-naive	Completed	Treatment	[101]
NCT00738361	II	Unresectable metastatic uveal melanoma	Paclitaxel albumin-stabilized nanoparticle formulation; single group	Completed	Treatment
NCT00404235	II	Unresectable stage IV melanoma	Paclitaxel albumin-stabilized nanoparticle formulation; chemotherapy-naïve; single group	Completed	Treatment	[100]
NCT02158520	II	Unresectable stage IV melanoma	Bevacizumab + paclitaxel albumin-stabilized nanoparticle formulation vs ipilimumab	Completed	Treatment	[103]
NCT01300533	I	Advanced or metastatic cancer including melanoma	BIND-014: targeted docetaxel polymeric nanoparticle; single group	Completed	Treatment	[104]
NCT02668536	I	Melanoma and UV ray damaged skin	Standard sunscreen vs sunscreen based on bioadhesive nanoparticles	Completed	Prevention	[105]
NCT04899908	II	Cancer with brain metastasis including melanoma	Stereotactic radiation with vs without AGuIX gadolinium-based nanoparticles	Recruiting	Treatment
NCT03739931	I	Advanced malignancies including melanoma	Lipid nanoparticle encapsulating mRNAs with vs without durvalumab	Recruiting	Treatment
NCT02106598	II	Head and neck melanoma	Silica nanoparticles with fluorescent cRGDY-PEG-Cy5.5-C dots for real-time image-guided intraoperative mapping of nodal metastases	Recruiting	Diagnostic

Completed and recruiting clinical studies currently listed in the NIH database of the U.S. National Library of Medicine(https://clinicaltrials.gov)

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