Fig. 4

Direct comparison of anatomically standardized amyloid PET images using CT and MRI. SPM analysis showed significantly (p < 0.001) higher and lower uptake of CT-based standardized PET images than MRI-based standardized PET images presented in a warm color scale (t value, from 0 to 10) and a cool color scale (t value, from 0 to − 10), respectively. The largest differences in the accumulation were visible in the brain stem. Higher uptake of CT-based standardized PET images was observed within the whole cerebellar VOI as a reference area (solid black area). In the supratentorial area, most of the significant differences in uptake were found outside the cortical target VOI (solid white area)