Comparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder

EJNMMI Research

Table 6 K_i results obtained from static scan using the static scan analysis compared with K_i results obtained from dynamic scan using Patlak analysis

Scan	First and second exponentials	Terminal exponential	V₀ (%)	K_i (ml min⁻¹ ml⁻¹)	Percentage difference	p Value	R	p value
Dynamic, Patlak	Population residual	Blood samples 30–90 min	64	0.0346 ± 0.009	–	–	–	–
Static	Population residual	Blood samples 30–60 min	43	0.0399 ± 0.010	+ 15%	< 0.001*	0.930	< 0.001*
Static	Population residual	Blood samples 30–60 min	52	0.0390 ± 0.010	+ 13%	0.002*	0.931	< 0.001*
Static	Population residual	Blood samples 30–90 min	43	0.0419 ± 0.011	+ 21%	< 0.001*	0.940	< 0.001*
Static	Population residual	Blood samples 30–90 min	64	0.0395 ± 0.011	+ 14%	0.001*	0.942	< 0.001*

Mean values ± SD are presented from 12 scans (Th7–10). Three different assumptions of V0 are applied and compared with Patlak analysis Ki values obtained using dynamic scans. Pearson’s correlation coefficient (R), *Level of statistical significance: p < 0.05