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Table 5 Comparison of Ki values obtained by nonlinear regression analysis with Ki values obtained by Patlak analysis using various input functions or static scan analysis

From: Comparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder

 

Nonlinear regression

Patlak analysis

Static scan

IDAIF

IDAIF

SPIF

(blood samples 30–60 min)

SPIF

(blood samples 30–90 min)

SPIF

(blood samples 30–90 min)

Ki (ml min−1 ml−1) ± SD

0.0415 ± 0.013

0.0337 ± 0.009

0.0340 ± 0.008

0.0346 ± 0.009

0.0395 ± 0.011

Percentage difference (p-value)

 − 18.8% (< 0.01*)

 − 18.1% (< 0.01*)

 − 16.6% (< 0.01*)

 − 4.8% (0.29)

V0 ± SD

0.39 ± 0.17

0.52 ± 0.25

0.64 ± 0.27

0.64

  1. Mean ± SD from 12 scans (Th7–10). *Level of statistical significance is p < 0.05. Image-derived AIFs (IDAIFs) were obtained from a TAC of left ventricle of the heart