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Table 5 Comparison of Ki values obtained by nonlinear regression analysis with Ki values obtained by Patlak analysis using various input functions or static scan analysis

From: Comparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder

  Nonlinear regression Patlak analysis Static scan
IDAIF IDAIF SPIF
(blood samples 30–60 min)
SPIF
(blood samples 30–90 min)
SPIF
(blood samples 30–90 min)
Ki (ml min−1 ml−1) ± SD 0.0415 ± 0.013 0.0337 ± 0.009 0.0340 ± 0.008 0.0346 ± 0.009 0.0395 ± 0.011
Percentage difference (p-value)  − 18.8% (< 0.01*)  − 18.1% (< 0.01*)  − 16.6% (< 0.01*)  − 4.8% (0.29)
V0 ± SD 0.39 ± 0.17 0.52 ± 0.25 0.64 ± 0.27 0.64
  1. Mean ± SD from 12 scans (Th7–10). *Level of statistical significance is p < 0.05. Image-derived AIFs (IDAIFs) were obtained from a TAC of left ventricle of the heart