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EJNMMI Research
Fig. 5 | EJNMMI Research

Fig. 5

From: Evaluation of single domain antibodies as nuclear tracers for imaging of the immune checkpoint receptor human lymphocyte activation gene-3 in cancer

Fig. 5

Visualization of huLAG-3 in mice bearing TC-1 and TC-1-huLAG-3 tumors using SPECT/CT imaging. A Schematic representation of the study design. B TC-1 and TC-1-huLAG-3 cells were injected subcutaneously at opposite hind legs of NU(NCr)Foxn1nu mice and allowed to grow tumors up till day 10. The graph shows the tumor volume in function of time as mean ± SD (n = 3). c Images of the SPECT/CT scans performed to evaluate the utility of selected 99mTc-labeled sdAbs to detect huLAG-3 expressed in tumors. The arrows indicate the tumors on the images (n = 3). MIP = Maximum Intensity Projection

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