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Table 5 PET uptake of [68Ga]Ga-4HMSA and[68Ga]Ga-citrate in BALB/c mice injected with CFA in the footpad at different time point post-CFA administration

From: [68Ga]Ga-4HMSA a promising new PET tracer for imaging inflammation

Time post-CFA administration

[68Ga]Ga-4HMSA (%ID/g)

[68Ga]Ga-citrate (%ID/g)

(Day)

Inflamed paw

Normal paw

Inflamed paw

Normal paw

1

2.13 ± 0.61**

0.78 ± 0.15

2.18 ± 1.07*

0.92 ± 0.49

2

1.77 ± 0.61*

0.91 ± 0.23

1.54 ± 0.48*

0.76 ± 0.08

3

1.07 ± 0.26**

0.69 ± 0.18

1.01 ± 0.29**

0.45 ± 0.12

7

1.49 ± 0.54

0.54 ± 0.10

1.40 ± 0.62

0.50 ± 0.10

  1. Two-tailed independent Student’s t-test. non-significant: p > 0.05; *: p ≤ 0.05; **: p ≤ 0.01