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Table 5 PET uptake of [68Ga]Ga-4HMSA and[68Ga]Ga-citrate in BALB/c mice injected with CFA in the footpad at different time point post-CFA administration

From: [68Ga]Ga-4HMSA a promising new PET tracer for imaging inflammation

Time post-CFA administration [68Ga]Ga-4HMSA (%ID/g) [68Ga]Ga-citrate (%ID/g)
(Day) Inflamed paw Normal paw Inflamed paw Normal paw
1 2.13 ± 0.61** 0.78 ± 0.15 2.18 ± 1.07* 0.92 ± 0.49
2 1.77 ± 0.61* 0.91 ± 0.23 1.54 ± 0.48* 0.76 ± 0.08
3 1.07 ± 0.26** 0.69 ± 0.18 1.01 ± 0.29** 0.45 ± 0.12
7 1.49 ± 0.54 0.54 ± 0.10 1.40 ± 0.62 0.50 ± 0.10
  1. Two-tailed independent Student’s t-test. non-significant: p > 0.05; *: p ≤ 0.05; **: p ≤ 0.01