Table 4 Predictors of PFS by univariate analysis based on PET/CT results after application of IMPeTUs
IMPeTUs criteria | PFS | |
|---|---|---|
Median [95% CI] | ||
Baseline PET/CT | Follow-up PET/CT | |
Bone marrow uptake, DS score | Â | Â |
≤ 3 | 47.2 [31.8–69.6] | 31.8 [22.6–51.8] |
> 3 | 34.7 [17.9–72.1] | 41.2 [41.2–NA] |
No. of focal, hypermetabolic lesions | Â | Â |
F1 (none) | NA [72.1–NA]* | 43.5 [22.6–NA]** |
F2 (1–3) | 47.5 [34.5–69.6]* | 37.1 [28.5–NA]** |
F3 (4–10) | 38.2 [31.6–NA]* | 15.2 [1.8–NA]** |
F4 (> 10) | 21.4 [13.3–NA]* | 13.3 [7.0–NA]** |
Uptake of the hottest focal lesion, DS | Â | Â |
≤ 3 | NA | 31.7 [22.6–51.8]¶ |
> 3 | NA | 24.0 [7.0–NA]¶ |
No. of lytic lesions | Â | Â |
L1 (none) | 42.8 [24.8–NA] | NA [36.1–NA] |
L2 (1–3) | 54.1 [36.8–NA] | 46.7 [28.4–NA] |
L3 (4–10) | 24.8 [20.1–NA] | 11.3 [1.8–NA] |
L4 (> 10) | 39.3 [31.6–61.7] | 26.9 [19.6–59.1] |
Presence of at least one fracture | Â | Â |
No | 47.5 [31.8–72.1] | 41.4 [26.9–NA] |
Yes | 35.7 [24.8–61.1] | 28.5 [19.6–59.1] |
Presence of PMD | Â | Â |
No | 49.3 [38.2–NA]# | 35.6 [22.6–51.8] |
Yes | 34.5 [24.8–54.5]# | NA° |
Presence of EMD | Â | Â |
No | 43.9 [31.8–61.7]§ | 37.6 [22.6–59.3] |
Yes | 17.2 [9.4–NA]§ | 24.8 [2.2–NA] |