Fig. 2
From: Rationale for MYC imaging and targeting in pancreatic cancer
Imaging of MYC. A Scheme for non-invasive annotating the MYC status. The TFRC gene is a MYC target. The Transferrin receptor can be imaged with a radiotracer, here 89Zr-labeled transferrin (TF) or 68Ga-citrate, which binds transferrin (TF). Overexpression of MYC leads to increased TFRC expression and augmented PET signal. B MYC and control Input ChIP-Seq data of human PDAC cells (MiaPaCa-2) published by Bhattacharyya et al. 2020 [36], were analyzed for specific binding of MYC to the TFRC gene. In addition, the exon structure of the TFRC gene is depicted (black boxes). C A mRNA expression dataset of human PDAC were retrieved via the publication of Bailey et al. [22] and curated as described [52]. A gene set enrichment analysis (GSEA) of Hallmark signatures via the GeneTrial 3.0 platform [110] was conducted comparing PDACs with TFRC mRNA expression in the highest quartile (Q4) versus PDACs in the quartiles Q1, Q2, and Q3. Each dot represents a significant hallmark signature. The MYC HALLMARK (v1) signature is highlighted in red