Fig. 7

Comparison of µPET images (MIPs of static scans; αvβ3, α5β1, αvβ6: 75 min p.i.; αvβ8: 60 min p.i.) in SCID mice bearing subcutaneous xenografts of integrin-expressing tumor cell lines (M21: αvβ3 and α5β1; MeWo: αvβ8; H2009: αvβ6) for the radiolabeled monomers ¹⁸F-Galacto-RGD [83], ⁶⁸ Ga-NODAGA-FR366 [102], ⁶⁸ Ga-TRAP-AvB8 [34], and ⁶⁸ Ga-TRAP-SDM17 [32], with their corresponding TRAP trimers ⁶⁸ Ga-Avebetrin [27, 83], ⁶⁸ Ga-Aquibeprin [27], ⁶⁸ Ga-Triveoctin [104], and ⁶⁸ Ga-TRAP(SDM17)₃ [105], respectively. Structures of comprised integrin ligands (see Fig. 2) are highlighted in blue. IC₅₀ values (given in nM) are denoted for the respective targeted integrins (see left column). Time-activity curves in the right column were derived from ROI-based analysis of 90-min dynamic µPET scans (the high initial uptakes for ¹⁸F-Galacto-RGD and ⁶⁸ Ga-NODAGA-FR366 are signal crosstalk artifacts resulting from non-optimal tumor position close to the main vein)