Fig. 6From: There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomographySynthesis of trimeric TRAP bioconjugates. The preferred route B for elaboration of trimeric integrin ligands by means of 'click chemistry' (CuAAC) is indicated by red arrows [91]. Of note, the CuAAC coupling was occasionally conducted with azide-decorated integrin ligands and alkyne-functionalized TRAP (obtained by amide coupling of propargyl amine, H2N–CH2–C≡CH, in step 1), e.g., for synthesis of 68 Ga-Aquibeprin (see Fig. 7)Back to article page