From: Sex correction improves the accuracy of clinical dopamine transporter imaging
Variable group | Variable | All | Normal DAT | Abnormal or borderline DAT | P valuea | P-value correctedb |
---|---|---|---|---|---|---|
Demographics | n | 40 | 26 | 14 | – | – |
Age (years) | 66.8 (9.0) | 68.2 (9.7) | 64.2 (7.3) | 0.18 | – | |
Sex (m/f) | 21/19 | 10/16 | 11/3 | 0.02 | – | |
Motor symptoms | MDS-UPDRS motor score | 6.6 (5.5) | 7.2 (5.7) | 5.5 (5.1) | 0.23 | 1.00 |
Premotor and non-motor symptoms | NMSS total score | 16.2 (16.5) | 19.1 (19.3) | 10.9 (7.3) | 0.44 | 1.00 |
RBD (yes/no) | 5/35 | 3/23 | 2/12 | 1.00 | 1.00 | |
Constipation | 0.5 (1.5) | 0.6 (1.7) | 0.4 (1.1) | 0.94 | 1.00 | |
Hyposmia | 0.3 (1.4) | 0.3 (1.6) | 0.3 (1.1) | 0.99 | 1.00 | |
Cognition | MMSE | 28.0 (2.1) | 28.2 (2.2) | 27.6 (1.8) | 0.22 | 1.00 |
Mood and anxiety | BDI | 2.6 (3.9) | 3.8 (4.4) | 0.5 (0.9) | 0.02 | 0.17 |
BAI | 4.2 (4.4) | 5.6 (4.4) | 1.6 (3.1) | < 0.001 | < 0.001 | |
DAT binding | Caudate | 2.58 (0.32) | 2.73 (0.25) | 2.29 (0.21) | < 0.001 | < 0.001 |
Putamen | 2.36 (0.32) | 2.54 (0.24) | 2.04 (0.16) | < 0.001 | < 0.001 | |
Putamen asymmetry index | 0.01 (0.04) | -0.0008 (0.04) | 0.03 (0.04) | 0.02 | – | |
Putamen/caudate ratio | 0.92 (0.05) | 0.93 (0.05) | 0.89 (0.05) | 0.03 | – |