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Table 1 Demographic and clinical characteristics of healthy volunteers with normal and abnormal striatal DAT binding

From: Sex correction improves the accuracy of clinical dopamine transporter imaging

Variable group

Variable

All

Normal DAT

Abnormal or borderline DAT

P valuea

P-value correctedb

Demographics

n

40

26

14

 

Age (years)

66.8 (9.0)

68.2 (9.7)

64.2 (7.3)

0.18

 

Sex (m/f)

21/19

10/16

11/3

0.02

Motor symptoms

MDS-UPDRS motor score

6.6 (5.5)

7.2 (5.7)

5.5 (5.1)

0.23

1.00

Premotor and non-motor symptoms

NMSS total score

16.2 (16.5)

19.1 (19.3)

10.9 (7.3)

0.44

1.00

 

RBD (yes/no)

5/35

3/23

2/12

1.00

1.00

 

Constipation

0.5 (1.5)

0.6 (1.7)

0.4 (1.1)

0.94

1.00

 

Hyposmia

0.3 (1.4)

0.3 (1.6)

0.3 (1.1)

0.99

1.00

Cognition

MMSE

28.0 (2.1)

28.2 (2.2)

27.6 (1.8)

0.22

1.00

Mood and anxiety

BDI

2.6 (3.9)

3.8 (4.4)

0.5 (0.9)

0.02

0.17

 

BAI

4.2 (4.4)

5.6 (4.4)

1.6 (3.1)

 < 0.001

 < 0.001

DAT binding

Caudate

2.58 (0.32)

2.73 (0.25)

2.29 (0.21)

 < 0.001

 < 0.001

 

Putamen

2.36 (0.32)

2.54 (0.24)

2.04 (0.16)

 < 0.001

 < 0.001

 

Putamen asymmetry index

0.01 (0.04)

-0.0008 (0.04)

0.03 (0.04)

0.02

 

Putamen/caudate ratio

0.92 (0.05)

0.93 (0.05)

0.89 (0.05)

0.03

  1. Values are means (SD) or n
  2. aMann-Whitney U-test, independent-samples t-test or Fisher’s exact test
  3. bBonferroni correction to adjust for multiple comparisons for two DAT binding regions and for eight symptom scales and questionnaires. Numbers of missing values: BAI = 1