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Table 1 Demographic and clinical characteristics of healthy volunteers with normal and abnormal striatal DAT binding

From: Sex correction improves the accuracy of clinical dopamine transporter imaging

Variable group Variable All Normal DAT Abnormal or borderline DAT P valuea P-value correctedb
Demographics n 40 26 14
  Age (years) 66.8 (9.0) 68.2 (9.7) 64.2 (7.3) 0.18
  Sex (m/f) 21/19 10/16 11/3 0.02
Motor symptoms MDS-UPDRS motor score 6.6 (5.5) 7.2 (5.7) 5.5 (5.1) 0.23 1.00
Premotor and non-motor symptoms NMSS total score 16.2 (16.5) 19.1 (19.3) 10.9 (7.3) 0.44 1.00
  RBD (yes/no) 5/35 3/23 2/12 1.00 1.00
  Constipation 0.5 (1.5) 0.6 (1.7) 0.4 (1.1) 0.94 1.00
  Hyposmia 0.3 (1.4) 0.3 (1.6) 0.3 (1.1) 0.99 1.00
Cognition MMSE 28.0 (2.1) 28.2 (2.2) 27.6 (1.8) 0.22 1.00
Mood and anxiety BDI 2.6 (3.9) 3.8 (4.4) 0.5 (0.9) 0.02 0.17
  BAI 4.2 (4.4) 5.6 (4.4) 1.6 (3.1)  < 0.001  < 0.001
DAT binding Caudate 2.58 (0.32) 2.73 (0.25) 2.29 (0.21)  < 0.001  < 0.001
  Putamen 2.36 (0.32) 2.54 (0.24) 2.04 (0.16)  < 0.001  < 0.001
  Putamen asymmetry index 0.01 (0.04) -0.0008 (0.04) 0.03 (0.04) 0.02
  Putamen/caudate ratio 0.92 (0.05) 0.93 (0.05) 0.89 (0.05) 0.03
  1. Values are means (SD) or n
  2. aMann-Whitney U-test, independent-samples t-test or Fisher’s exact test
  3. bBonferroni correction to adjust for multiple comparisons for two DAT binding regions and for eight symptom scales and questionnaires. Numbers of missing values: BAI = 1