A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68Ga-DOTATATE in patients without neuroendocrine tumors

EJNMMI Research

Table 3 Sensitivity analysis results for the PK output parameter area under the concentration–time curve. Only sensitivity values < −0.5 or > 0.5 were reported

Compartment	PK output parameter	Input parameter	Sensitivity value
Spleen	AUC	⁶⁸Ga-DOTATATE dose	1.03
Spleen	AUC	Fraction vascular of spleen	0.53
Liver	AUC	⁶⁸Ga-DOTATATE dose	1.02
Liver	AUC	Liver volume	− 0.61
Thyroid	AUC	Thyroid volume	− 0.96
Thyroid	AUC	⁶⁸Ga-DOTATATE dose	0.96