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Table 3 Sensitivity analysis results for the PK output parameter area under the concentration–time curve. Only sensitivity values < −0.5 or > 0.5 were reported

From: A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68Ga-DOTATATE in patients without neuroendocrine tumors

Compartment PK output parameter Input parameter Sensitivity value
Spleen AUC 68Ga-DOTATATE dose 1.03
Spleen AUC Fraction vascular of spleen 0.53
Liver AUC 68Ga-DOTATATE dose 1.02
Liver AUC Liver volume − 0.61
Thyroid AUC Thyroid volume − 0.96
Thyroid AUC 68Ga-DOTATATE dose 0.96
  1. AUC: area under the concentration–time curve (0–24 h)