Parameter | Initial or fixed value | Fitted value | References |
---|---|---|---|
Molecular weight | 1502.3 g/mol | ||
Lipophilicity | − 3.69 | [41] | |
pKa (strongest acidic) | 0.46 | [40] | |
pKa (strongest basic) | 10.3 | [40] | |
KD | 0.20 nmol/L | ||
koff | 0.012 min−1 | ||
kint | 0.161 min−1 | [45] | |
kdeg | 0.00012 min−1 | [16] | |
Fraction unbound | 0.69 | [42] | |
Interstitial SSTR2 concentration spleen | 100 nmol/L | 112.0 nmol/L | |
Interstitial SSTR2 concentration liver | 15 nmol/L | 20.2 nmol/L | |
Interstitial SSTR2 concentration thyroid | 5.0 nmol/L | 4.71 nmol/L | [8] |
Renal plasma clearance | 0.45 ml/min/kg | 0.67 ml/min/kg | [29] |