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Table 2 All initial, fixed and fitted input parameters for the whole-body PBPK model of 68Ga-DOTATATE

From: A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68Ga-DOTATATE in patients without neuroendocrine tumors

Parameter Initial or fixed value Fitted value References
Molecular weight 1502.3 g/mol   [40, 41]
Lipophilicity − 3.69   [41]
pKa (strongest acidic) 0.46   [40]
pKa (strongest basic) 10.3   [40]
KD 0.20 nmol/L   [24, 43]
koff 0.012 min−1   [24, 43]
kint 0.161 min−1   [45]
kdeg 0.00012 min−1   [16]
Fraction unbound 0.69   [42]
Interstitial SSTR2 concentration spleen 100 nmol/L 112.0 nmol/L [8, 16]
Interstitial SSTR2 concentration liver 15 nmol/L 20.2 nmol/L [8, 16]
Interstitial SSTR2 concentration thyroid 5.0 nmol/L 4.71 nmol/L [8]
Renal plasma clearance 0.45 ml/min/kg 0.67 ml/min/kg [29]
  1. KD: equilibrium dissociation constant; koff: dissociation rate constant; kint: internalization rate; kdeg: degradation rate; SSTR: somatostatin receptor