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Table 2 All initial, fixed and fitted input parameters for the whole-body PBPK model of 68Ga-DOTATATE

From: A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68Ga-DOTATATE in patients without neuroendocrine tumors

Parameter

Initial or fixed value

Fitted value

References

Molecular weight

1502.3 g/mol

 

[40, 41]

Lipophilicity

− 3.69

 

[41]

pKa (strongest acidic)

0.46

 

[40]

pKa (strongest basic)

10.3

 

[40]

KD

0.20 nmol/L

 

[24, 43]

koff

0.012 min−1

 

[24, 43]

kint

0.161 min−1

 

[45]

kdeg

0.00012 min−1

 

[16]

Fraction unbound

0.69

 

[42]

Interstitial SSTR2 concentration spleen

100 nmol/L

112.0 nmol/L

[8, 16]

Interstitial SSTR2 concentration liver

15 nmol/L

20.2 nmol/L

[8, 16]

Interstitial SSTR2 concentration thyroid

5.0 nmol/L

4.71 nmol/L

[8]

Renal plasma clearance

0.45 ml/min/kg

0.67 ml/min/kg

[29]

  1. KD: equilibrium dissociation constant; koff: dissociation rate constant; kint: internalization rate; kdeg: degradation rate; SSTR: somatostatin receptor