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Fig. 1 | EJNMMI Research

Fig. 1

From: A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68Ga-DOTATATE in patients without neuroendocrine tumors

Fig. 1

Schematic overview of the developed 68Ga-DOTATATE PBPK model (a), with all organ compartments included and arrows representing blood flow. Each organ compartment consists of subcompartments (b), where peptide transfer from interstitial to intracellular space occurs by internalization of the SSTR2 receptor after peptide binding. *Intestinal compartment consists of small intestine (SSTR2 fraction = 0.09) and large intestine (SSTR2 fraction = 0.11). CLrenal: renal clearance; kint: internalization rate; kdeg: degradation rate; SSTRfr: somatostatin receptor fraction

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