Validate the accuracy of your tracer in multiple strains, and consider model-dependent influence of sexes, age and arthritis-inducing trigger |
Incorporate complementary immunological assays for cross-validating imaging findings, which will aid in the interpretation as well as better understanding tracer limitations |
Define a relevant outcome measure in inflammatory musculoskeletal diseases in consensus, involving multiple stakeholders, e.g. clinicians, pharmaceutical companies, and regulatory bodies, on the relevant pathophysiological endpoints |
Endorse the FAIR principle of your molecular imaging data in service of exchange of expertise across disciplines |
Use more frequently a large animal model (sheep, pig, dog) since data from such a model are more easily translated to humans |
Consider collaborative multi-centre studies, so that expertise in different disease models is combined |
Present a statistical substantiation for the number of animals that have been used in your study |
Report negative findings |
Report whether your preclinical study will be followed up by a further study in humans |