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Table 3 Overview of trials reporting on preoperative nuclear medicine imaging and computed tomography or magnetic resonance imaging for the prediction of postoperative liver failure

From: Comparison of nuclear imaging techniques and volumetric imaging for the prediction of postoperative mortality and liver failure in patients undergoing localized liver-directed treatments: a systematic review

Author LF defined LF event rate Preset cutoff value studied Post hoc cutoff value established Only descriptive analysis LF versus no LF comparison Key diagnostic characteristics reported Cutoff value predictive in univariable regression analysis Cutoff value predictive in multivariable regression analysis
Chapelle et al. [18] Yes 14% NMI/MRI/Combined: No NMI: No
MRI/Combined: Yesa
No NMI/MRI/Combined: Yes NMI: No
MRI/Combined: Yes
NMI: Yes
MRI: Yes
Combined: Yes
NMI: No
MRI: No
Combined: Yes
Chapelle et al. [27] Yes 1%b NMI: No
MRI: Yes
Combined: Yes
NMI/MRI/Combined: No Yes NR NR NR NR
Chapelle et al. [26] Yes 15% NMI/MRI: No
Combined: Yes
NMI/MRI/Combined: No No NMI/MRI/Combined: Yes NMI/MRI/Combined: Yes NMI: No
MRI: Yes
Combined: Yes
NMI: NR
MRI: NR
Combined: Yes
Cho et al. [14] Yes 5% NMI/CT/Combined: No NMI/CT/Combined: Yes No NMI/CT/Combined: Yes NMI/CT/Combined: Yes NMI: No
CT: Yes
Combined: Yes
NMI: NR
CT: No Combined: Yes
Cieslak et al. [21] Yes 2% NMI/CT: Yes NMI/CT: No Yes NR NR NR NR
de Graaf et al. [10] Yes 16% NMI: No
CT: Yes
NMI: Yes
CT: No
No NMI/CT: Yes NMI/CT: Yes NMI/CT: NR NMI/CT: NR
Dinant et al. [19] Yes 13% NMI/CT: No NMI: Yes
CT: No
No NMI/CT: Yes NMI/CT: Yes NMI: Yes
CT: NR
NMI: Yes
CT: NR
Hayashi et al. [20] Yes 8% NMI/CT: Yes NMI/CT: No No NMI/CT: NR NMI/CT: NR NMI: Yes
CT: No
NMI/CT: NR
Hirai et al. [24] Yes 23% NMI/CT: No NMI/CT: Yes No NMI/CT: Yes NMI/CT: Yes NMI/CT: NR NMI/CT: NR
Kokudo et al. [17] Yesc 13% NMI/CT/Combined: No NMI: No
Combined: Yes
CT: No
No NMI/CT/Combined: Yes NMI/CT/Combined: NR NMI/CT/Combined: NR NMI: No
CT: NR
Combined: Yes
Nanashima et al. ≠ [32] Yes 6% NMI/CT: No NMI/CT: Yes No NMI/CT: Yes NMI/CT: NR NMI/CT: NR NMI: No
CT: Yes
Nanashima et al. [37] No 4% NMI: Yes
CT: No
NMI/CT: No Yes NR NR NR NR
Okabe et al. [30] Yes PLD: 7%
LF: 2%
NMI: No
CT: Yes
NMI: Yes (PLD)
CT: No
No NMI/CT: Yes (PLD) NMI: Yes (PLD)
CT: NR
NMI/CT: NR NMI: Yes
CT: NR (PLD)
Olthof et al. [22] Yes 23% NMI/CT: Yes NMI/CT: Yes No NMI/CT: Yes NMI/CT: Yes NMI/CT: Yes NMI: Yes
CT: No
Rassam et al. ≠ [23] Yes 10% (LF only) NMI: Yes
CT: No
NMI: No
CT: No
No NMI/CT: Yes NMI/CT: NR NMI/CT: NR NMI/CT: NR
Serenari et al. [28] Yes 20%d NMI/CT/MRI: No NMI: Yes
CT/MRI: No
No NMI/CT/MRI: Yes NMI: Yes
CT/MRI: NR
NMI/CT/MRI: NR NMI/CT/MRI: NR
Serenari et al. [29] Yes 33% NMI: No
CT: Yes
NMI/CT: No NMI: No
CT: Yes
NMI: Yes
CT: NR
NMI/CT: NR NMI/CT: NR NMI/CT: NR
Yoshida et al. [31] Yes 6% NMI/CT/Combined: No NMI/Combined: Yes
CT: No
No NMI/CT: Yes
Combined: NR
NMI/Combined: Yes
CT: NR
NMI/CT/Combined: NR NMI: Yes
CT: No
Combined: NR
Yumoto et al. [16] Yesc 17% NMI/CT: No NMI: Yes
CT: No
No NMI/CT: Yes NMI: Yes
CT: NR
NMI/CT: NR NMI/CT: NR
  1. LF: liver failure; NMI: nuclear medicine imaging; CT: computed tomography; MRI: magnetic resonance imaging; NR: not reported; and PLD: postoperative liver dysfunction
  2. aOnly patients with a preoperative FLRV% > 25% were resected and included in the study
  3. b1% of patients in the interventional group developed LF postoperatively, but in the 88 patients in the prior study by Chapelle et al. the liver failure rate was 14%, also reported in the table above
  4. cSigns of postoperative LF
  5. dIncluding four patients who developed LF after stage 2 of the ALPPS procedure and excluding one patient who developed LF after stage 1 of the ALPPS procedure