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EJNMMI Research

Table 3 Overview of trials reporting on preoperative nuclear medicine imaging and computed tomography or magnetic resonance imaging for the prediction of postoperative liver failure

From: Comparison of nuclear imaging techniques and volumetric imaging for the prediction of postoperative mortality and liver failure in patients undergoing localized liver-directed treatments: a systematic review

Author

LF defined

LF event rate

Preset cutoff value studied

Post hoc cutoff value established

Only descriptive analysis

LF versus no LF comparison

Key diagnostic characteristics reported

Cutoff value predictive in univariable regression analysis

Cutoff value predictive in multivariable regression analysis

Chapelle et al. [18]

Yes

14%

NMI/MRI/Combined: No

NMI: No

MRI/Combined: Yesa

No

NMI/MRI/Combined: Yes

NMI: No

MRI/Combined: Yes

NMI: Yes

MRI: Yes

Combined: Yes

NMI: No

MRI: No

Combined: Yes

Chapelle et al. [27]

Yes

1%b

NMI: No

MRI: Yes

Combined: Yes

NMI/MRI/Combined: No

Yes

NR

NR

NR

NR

Chapelle et al. [26]

Yes

15%

NMI/MRI: No

Combined: Yes

NMI/MRI/Combined: No

No

NMI/MRI/Combined: Yes

NMI/MRI/Combined: Yes

NMI: No

MRI: Yes

Combined: Yes

NMI: NR

MRI: NR

Combined: Yes

Cho et al. [14]

Yes

5%

NMI/CT/Combined: No

NMI/CT/Combined: Yes

No

NMI/CT/Combined: Yes

NMI/CT/Combined: Yes

NMI: No

CT: Yes

Combined: Yes

NMI: NR

CT: No Combined: Yes

Cieslak et al. [21]

Yes

2%

NMI/CT: Yes

NMI/CT: No

Yes

NR

NR

NR

NR

de Graaf et al. [10]

Yes

16%

NMI: No

CT: Yes

NMI: Yes

CT: No

No

NMI/CT: Yes

NMI/CT: Yes

NMI/CT: NR

NMI/CT: NR

Dinant et al. [19]

Yes

13%

NMI/CT: No

NMI: Yes

CT: No

No

NMI/CT: Yes

NMI/CT: Yes

NMI: Yes

CT: NR

NMI: Yes

CT: NR

Hayashi et al. [20]

Yes

8%

NMI/CT: Yes

NMI/CT: No

No

NMI/CT: NR

NMI/CT: NR

NMI: Yes

CT: No

NMI/CT: NR

Hirai et al. [24]

Yes

23%

NMI/CT: No

NMI/CT: Yes

No

NMI/CT: Yes

NMI/CT: Yes

NMI/CT: NR

NMI/CT: NR

Kokudo et al. [17]

Yesc

13%

NMI/CT/Combined: No

NMI: No

Combined: Yes

CT: No

No

NMI/CT/Combined: Yes

NMI/CT/Combined: NR

NMI/CT/Combined: NR

NMI: No

CT: NR

Combined: Yes

Nanashima et al. ≠ [32]

Yes

6%

NMI/CT: No

NMI/CT: Yes

No

NMI/CT: Yes

NMI/CT: NR

NMI/CT: NR

NMI: No

CT: Yes

Nanashima et al. [37]

No

4%

NMI: Yes

CT: No

NMI/CT: No

Yes

NR

NR

NR

NR

Okabe et al. [30]

Yes

PLD: 7%

LF: 2%

NMI: No

CT: Yes

NMI: Yes (PLD)

CT: No

No

NMI/CT: Yes (PLD)

NMI: Yes (PLD)

CT: NR

NMI/CT: NR

NMI: Yes

CT: NR (PLD)

Olthof et al. [22]

Yes

23%

NMI/CT: Yes

NMI/CT: Yes

No

NMI/CT: Yes

NMI/CT: Yes

NMI/CT: Yes

NMI: Yes

CT: No

Rassam et al. ≠ [23]

Yes

10% (LF only)

NMI: Yes

CT: No

NMI: No

CT: No

No

NMI/CT: Yes

NMI/CT: NR

NMI/CT: NR

NMI/CT: NR

Serenari et al. [28]

Yes

20%d

NMI/CT/MRI: No

NMI: Yes

CT/MRI: No

No

NMI/CT/MRI: Yes

NMI: Yes

CT/MRI: NR

NMI/CT/MRI: NR

NMI/CT/MRI: NR

Serenari et al. [29]

Yes

33%

NMI: No

CT: Yes

NMI/CT: No

NMI: No

CT: Yes

NMI: Yes

CT: NR

NMI/CT: NR

NMI/CT: NR

NMI/CT: NR

Yoshida et al. [31]

Yes

6%

NMI/CT/Combined: No

NMI/Combined: Yes

CT: No

No

NMI/CT: Yes

Combined: NR

NMI/Combined: Yes

CT: NR

NMI/CT/Combined: NR

NMI: Yes

CT: No

Combined: NR

Yumoto et al. [16]

Yesc

17%

NMI/CT: No

NMI: Yes

CT: No

No

NMI/CT: Yes

NMI: Yes

CT: NR

NMI/CT: NR

NMI/CT: NR

  1. LF: liver failure; NMI: nuclear medicine imaging; CT: computed tomography; MRI: magnetic resonance imaging; NR: not reported; and PLD: postoperative liver dysfunction
  2. aOnly patients with a preoperative FLRV% > 25% were resected and included in the study
  3. b1% of patients in the interventional group developed LF postoperatively, but in the 88 patients in the prior study by Chapelle et al. the liver failure rate was 14%, also reported in the table above
  4. cSigns of postoperative LF
  5. dIncluding four patients who developed LF after stage 2 of the ALPPS procedure and excluding one patient who developed LF after stage 1 of the ALPPS procedure
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